FlandersBio on Twitter

Follow us on Twitter

Life sciences database

Databank life sciences

in het nederlands in english

FlandersBio offers an up-to-date life sciences database with detailed information about all FlandersBio members.

FlandersBio beschikt over een geüpdate life sciences databank met een gedetailleerd overzicht van alle FlandersBio-ledenbedrijven.

KU Leuven - Experimental Genetics Group

Website: http://www.med.kuleuven.be/legtegg
Email:
Phone: +32 16 34 58 88
FlandersBio Member
More address details

Business Focus

The Experimental Genetics Group (LEGTEGG) is an academic research-group dedicated to generate transgenic mice as pre-clinical models to study fundamental mechanisms that are defective in Alzheimer's disease.

Tags

Company Profile

LEGTEGG is an academic research-group focusing on fundamental mechanisms in brain that become defective by ageing in Alzheimer's disease (AD). The group generated and characterized highly relevant transgenic mouse models that recapitulate the amyloid and tau-pathology of AD, separately and combined in bigenic mice. The pre-clinical models are highly informative for fundamental and translational studies of neurodegeneration, for modulating proteinases (ADAM10, BACE, PS1) and kinases (GSK3, cdk5), for pharmacological and immunological intervention. The mouse models are validated for diagnostic and therapeutic applications in-house and in numerous academic and industrial collaborations, and are operationally licensed to our KU Leuven spin-off reMYND (°2002).

Science & Technology or Services

  • generation and characterization of transgenic mice as pre-clinical models
  • phenotyping with behavioral, biochemical, pathological analysis
    • motor and cognitive behavior (water-maze, fear-conditioning, novel-object recognition, open field, rotarod)
    • western blotting, ELISA (brain, blood, cerebrospinal fluid)
    • brain histochemistry and immuno-histochemistry (amyloid, tau-pathology, image analysis)

Alliances

LEGTEGG is within Europe the only academic group with in-house transgenic mice with proven combined amyloid and tau-pathology. Besides fundamental interest from academia, our models attracted interest from biotech and pharma as pre-clinical test-banks, which service activities eventually resulted in the CRO reMYND. Numerous academic collaborations resulted, either "pro-deo" or funded, e.g. FP7-NEURO.GSK3,  EEG-NEURAD, EURON PhD-school, Marie-Curie PhD training grants. Next to fundamental studies (FWO-Vlaanderen) we engage in translational industrial contracts (direct and IWT), e.g. Innogenetics, J&J, reMYND, Ablynx, AC-Immune, MSD, Serono, GSK, Abbott, Sanofi, ...

More info

Address: Campus Gasthuisberg O&N1-06.602
Herestraat 49
3000 Leuven
Belgium

Route: Via Google Maps
Website: http://www.med.kuleuven.be/legtegg

Phone: +32 16 34 58 88
Fax: +32 16 34 58 71
Foundation date: 1991
Email: fred.vanleuven@med.kuleuven.be...

Become a Member

Listen to some testimonials from companies that are a member of FlandersBio and discover the benefits of membership

Read more

Z Life Sciences

Looking behind the scenes of the vibrant life sciences sector in Flanders!

YouTube

Biotechstockmarket

Belgian biotech on Euronext

Belgian biotech on Euronext

FlandersBio Members

Gedeon Richter Benelux Hudson Belgium XiTechniX Ghent University Yakult Honsha European Research Center for Microbiology JSR Micro QuintilesIMS Flemish Biobank Initiative Akcelis Altran Turnstone Communications Cartagenia, a part of Agilent Technologies Cochlear Technology Centre Belgium Spinnovation Analytical Rialto Recruitment Crowell & Moring Institute of Tropical Medicine Antwerp (ITM) Biotechsubsidy- Patergrus AIM ttopstart - science & business consultants VITO Q People Thema Group Belgium - Partner in Life Science Recruitment Promethera Biosciences Belgian Coordinated Collections of Micro-organisms BIPP, BIP eProcurement Platform for Life Sciences NautaDutilh Bioqube Ventures Xendo

View all members

Life Sciences Map

Life Sciences Map

View Life Sciences Map

Back to top

Print